"Fatores prognósticos e alterações da proteína mdm2 no lipossarcoma primário de extremidades" / Prognostic factors and expression of protein mdm2 in patients with primary extremity liposarcoma

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

The purpose of this was to study the expression by imunohistochemistry of mdm2 and your correlation with anatomopathological selected variables, aiming at identifying prognostic factors concerning to local recurrence free survival (LRFS), metastases free survival (MFS) and overall survival (OS) in patients with liposarcomas primary extremities. This study included 25 patients registred in the Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - Brazil, from 1968 to 2004. The accumulated survival probabilities were calculated by Kaplan-Meier method and survival curves were compared using the logrank test. Statistical significance was defined as a p value less than 0,05. Associations between expression of mdm2 and other variables were analyzed using Fischer’s exact test. The expression by imunohistochemistry of mdm2 was not significant factor for LRFS, MFS or OS. The adverse factors for LRFS in univariate analysis were male gender (p = 0,023), pleomorfic histologic subtypes (p = 0,027) and high grade tumor (p = 0,007). For MFS age <50 years (p = 0,040), male gender (p = 0,040), pleomorfic histologic subtypes (p <0,001) and high grade tumor (p = 0,003) had worse prognostic. Negative prognostic factors for OS were age <50 years (p = 0,040), male gender (p = 0,040), pleomorfic histologic subtypes (p <0,001) and high grade tumor (p = 0,003).

ASSUNTO(S)

proto-oncogene proteins extremidade inferior lipossarcoma/patologia proteínas proto-oncogênicas lower extremity liposarcoma/surgery prognosis extremidade superior immunohistochemistry prognóstico imunohistoquímica lipossarcoma/cirurgia liposarcoma/pathology upper extremity

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