Fatores de influência de cepas de Candida albicans isoladas de fumantes e não-fumantes / Virulence factors of Candida albicans strains isolated from smokers and non-smokers / Virulence factors of Candida albicans strains isolated from smokers and non-smokers / Fatores de influência de cepas de Candida albicans isoladas de fumantes e não-fumantes

AUTOR(ES)

Ana Claudia Santos de Azevedo Izidoro

DATA DE PUBLICAÇÃO

2007

RESUMO

The cigarette smoke contains substances that can be degraded by enzymes of Candida species, been used like nutrients and converted to carcinogen end products. The purpose of this study was evaluated the carriage of Candida species and analyse the extracellular proteolytic activities of Candida isolates from healthy adults non-smokers and smokers. One hundred adults (42 non-smokers and 58 smokers) were studied. The samples were collected from intra oral swabs and smears from dorsum of tongue, right and left jugal mucosa each. The identification of species of Candida was made using the culture medium CHROMagarCandida. The carriage of the gender Candida was 28,57% in the non-smokers individuals and 39,65% in the smokers (P = 0,254). Candida albicans was the most prevalent one between the two groups, being isolated in 78.57% in non-smokers, and 72.41% in smokers. Other species found were C. parapsilosis, C. glabrata, and C. tropicalis. From the positive individuals was random one strain of C. albicans, comprised 32 strains that were evaluated regarding the proteolytic activity of the following enzymes: secreted aspartyl-protease (Sap), phospholipase, chondroitinase, esterase-lipase, and haemolysin. Regarding the hydrolytic enzymes, there was bigger enzymatic activity in the group of non-smokers, in all studied enzymes, with significant statistical difference between both groups in the activity of phospholipase, that was bigger in the strains of non-smokers (P = 0,013). The results obtained in this study have shown that the smoking do not alter significantly the carriage of Candida spp., neither the enzymatic activity of C. albicans strains, except the activity of phospholipase.

ASSUNTO(S)

candida albicans fumantes enzimas dentistry candida albicans tobacco habit smoking oral medicine estomatologia fumo - vício odontologia odontologia - dissertações enzymes

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