Expression of estrogen and progesterone receptors in astrocytomas: a literature review

AUTOR(ES)

Tavares, Cléciton Braga, Gomes-Braga, Francisca das Chagas Sheyla Almeida, Costa-Silva, Danylo Rafhael, Escórcio-Dourado, Carla Solange, Borges, Umbelina Soares, Conde-Junior, Airton Mendes, Barros-Oliveira, Maria da Conceição, Sousa, Emerson Brandão, Barros, Lorena da Rocha, Martins, Luana Mota, Facina, Gil, da-Silva, Benedito Borges

FONTE

Clinics

DATA DE PUBLICAÇÃO

2016-08

RESUMO

Gliomas are the most common type of primary central nervous system neoplasm. Astrocytomas are the most prevalent type of glioma and these tumors may be influenced by sex steroid hormones. A literature review for the presence of estrogen and progesterone receptors in astrocytomas was conducted in the PubMed database using the following MeSH terms: “estrogen receptor beta” OR “estrogen receptor alpha” OR “estrogen receptor antagonists” OR “progesterone receptors” OR “astrocytoma” OR “glioma” OR “glioblastoma”. Among the 111 articles identified, 13 studies met our inclusion criteria. The majority of reports showed the presence of estrogen and progesterone receptors in astrocytomas. Overall, higher tumor grades were associated with decreased estrogen receptor expression and increased progesterone receptor expression.

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