Expression of cellular oncogenes during embryonic and fetal development of the mouse.
AUTOR(ES)
Slamon, D J
RESUMO
Cellular oncogenes are conserved with great fidelity across a broad span of evolution. This avid conservation suggests possible roles in critical physiologic functions. Little, however, is known about their activity in normal cellular processes. In this study, we examined the expression pattern of eight cellular oncogenes during embryonic and fetal development of the mouse. Five of these genes (c-myc, c-erb, c-Ha-ras, c-src, and c-sis) were expressed at appreciable levels, and four were modulated in a consistent manner during the course of prenatal development.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=392093Documentos Relacionados
- Methylation changes in the apolipoprotein AI gene during embryonic development of the mouse.
- Expression of the src and abl cellular oncogenes during development of Drosophila melanogaster.
- Expression of ras cellular oncogenes during development of Drosophila melanogaster.
- Fine structure of somatotrophs and mammotrophs during development of the dwarf (dw) mutant mouse.
- Expression of the mouse tyrosinase gene during embryonic development: recapitulation of the temporal regulation in transgenic mice.