Expressão imunoistoquímica das proteínas c-erbB-2 e vimentina em carcinomas epidermóides bucais em correlação com características clínicas e prognóstico / Protein expression by immunohistochemistry of c-erbB-2 and vimentin in oral squamous cell carcinoma correlated with clinical features and prognosis

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

About of malignancies in oral mucosa, 95% are represented by oral squamous cell carcinoma (OSCC). This disease is usually aggressive, with unpredictable biological behavior and poor prognosis and the local infiltration and consequent metastases the main cause of death of patients. The identification of molecular markers that may predict the clinical course of disease, guide the treatment as well as lead the development of new therapies that improve the rates of survival, has been the goal of many studies. This study examined the correlation of immunohistochemical expression of c-erbB-2 and vimentin with clinical features and prognosis of OSCC patients from the retrospective analysis of 65 cases. c-erbB-2 and vimentin were expressed in 61.54% and 70.8% of samples, respectively. There was no statistically significant correlation between the expression of these markers and clinical characteristics, but a tendency to vimentin expression in the lymph node status. The patients survival, was influenced by their gender, smoking habits the, clinical stage of disease, N index and modalities of treatment. The gender was the only independent prognostic factor detected. The immunohistochemical expression of c-erbB-2 and vimentin did not show up predictive of survival in oral cavity squamous cell carcinoma.

ASSUNTO(S)

erbb-2 vimentina carcinoma epidermóide vimentin erbb-2 prognosis prognóstico oral squamous cell carcinoma

ACESSO AO ARTIGO

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