Experimental Studies on Cholera Immunization II. Evidence for Protective Antitoxic Immunity Mediated by Serum Antibodies as Well as Local Antibodies
AUTOR(ES)
Holmgren, J.
RESUMO
By use of the ileal loop technique, the resistance to challenge with cholera enterotoxin was compared between unimmunized rabbits and rabbits immunized with toxin or toxoids. It was shown that subcutaneous as well as intraintestinal immunization induced protective immunity, the toxin being a better immunogen than Formalin-induced toxoid and much better than heat-induced toxoid. The relation between protection and serum antitoxin titer was poor, e.g., protection was seen in the absence of demonstrable serum antibodies. However, intravenous administration of antitoxic antiserum conferred some protection, suggesting that local as well as serum-mediated antitoxic immunity is operating in the host defence against cholera.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=422423Documentos Relacionados
- Antitoxic immunity in experimental cholera: protection, and serum and local antibody responses in rabbits after enteral and parenteral immunization.
- Production of antitoxic immunity by live oral cholera vaccine.
- Oral Immunization of Dogs with Purified Cholera Toxin, Crude Cholera Toxin, or B Subunit: Evidence for Synergistic Protection by Antitoxic and Antibacterial Mechanisms
- Antitoxic Cholera Immunity in Mice: Influence of Antigen Deposition on Antitoxin-Containing Cells and Protective Immunity in Different Parts of the Intestine
- Antitoxic immunity to cholera in dogs immunized orally with cholera toxin.
