Experimental models in vaccine research: malaria and leishmaniasis
AUTOR(ES)
Teixeira, C., Gomes, R.
FONTE
Braz J Med Biol Res
DATA DE PUBLICAÇÃO
01/02/2013
RESUMO
Animal models have a long history of being useful tools, not only to test and select vaccines, but also to help understand the elaborate details of the immune response that follows infection. Different models have been extensively used to investigate putative immunological correlates of protection against parasitic diseases that are important to reach a successful vaccine. The greatest challenge has been the improvement and adaptation of these models to reflect the reality of human disease and the screening of vaccine candidates capable of overcoming the challenge of natural transmission. This review will discuss the advantages and challenges of using experimental animal models for vaccine development and how the knowledge achieved can be extrapolated to human disease by looking into two important parasitic diseases: malaria and leishmaniasis.
Documentos Relacionados
- Animal models in biological and biomedical research - experimental and ethical concerns
- Suíno como modelo experimental na pesquisa biomédica: valores fisiológicos normais = Swine in biomedical research: normal physiological values
- Ethics review in research: Research governance also delays research
- Accident Research: Methods and Approaches
- Peer review in health services research: issues and problems.