Experimental Model of Saccular Abdominal Aortic Aneurysm in Swines with Pericardium Sac
AUTOR(ES)
Aquino, Maurício de Amorim, Barros, Svetlana Maria Wanderley de, Castro, Aldemar Araújo, Pitta, Guilherme Benjamin Brandão, Pereira, Adamastor Humberto
FONTE
Braz. J. Cardiovasc. Surg.
DATA DE PUBLICAÇÃO
2016-02
RESUMO
Abstract Objective: To consider modifications in an experimental model of saccular aortic aneurysm, aiming at better reproducibility, to be used in the development of vascular prostheses. Methods: Experimental study in two phases, developed in the Center of Experimental Surgery and Bioterium (CCEB) of the University of Health Sciences of Alagoas (UNCISAL), with 11 hybrid swine, female, mean weight of 20 ± 5 kg, according to modifications in the Perini technique was performed. In the first phase, the aneurysm was confectioned with bovine pericardial patch. In the second phase, fifteen days later, the patency of the aneurysms was confirmed by Doppler ultrasonography. The described variables were aortic and aneurysm sac patency, incidence of rupture, morbidity and mortality. The statistical analysis program used was STATA v.8. Results: All animals survived to the procedures. Surgical mean time was 73 minutes. Aneurysm rupture, proximal or distal aortic thrombosis, visceral or legs ischemia weren't observed. Parietal thrombus formation was observed in all of the aneurysms, two of which (18%; IC 95% = 3.98 - 48.84) were occluded and nine (82%; IC 95% = 51.15 - 96.01) were patent. Conclusion: In this series, the modifications carried out in the technique related to the surgical approach, race, anesthesia, and imaging exams reproduced the experimental model, reducing its costs, without hindering the analysis of the variables. The satisfactory patency ratio allows the method to be used in experimental models for the development of vascular prostheses.
Documentos Relacionados
- Modelo suino de aneurisma de aorta abdominal com bolsa de pericárdio bovino
- Endovascular treatment of huge saccular abdominal aortic aneurysm in a young Behcet patient: mid-term result
- Hybrid Treatment of Complex Aortic Arch Anomaly with Saccular Aneurysm
- Management of cholelithiasis in patients with abdominal aortic aneurysm.
- The Role of Vaccinium Myrtillus in the Prevention of Renal Injury in an Experimental Model of Ruptured Abdominal Aortic Aneurysm