Existence of multiple immunodeterminants in the type-specific capsular substance of group B type Ia streptococci.
AUTOR(ES)
Kane, J A
RESUMO
Rabbits immunized with group B, type Ia streptococci produce two distinct populations of protective antibodies. Evidence is presented indicating that these antibodies are directed against two major immunodeterminants which coexist in the specific type Ia antigen. Immunochemical data, using purified antibody preparations, indicate that the type substance, a sialic acid polymer consisting of galactose, glucose, glucosamine, and sialic acid, possesses two distinct immunodominant determinants, terminal sialic acid residues and a galactosyl oligosaccharide. Antibodies directed against either of these determinants were shown to possess in vivo and in vitro opsonic capabilities.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=422288Documentos Relacionados
- Type-Specific Antigens of Group B Type Ic Streptococci
- Type-Specific Antigens of Group B Type Ic Streptococci
- Induction of tumor necrosis factor alpha by the group- and type-specific polysaccharides from type III group B streptococci.
- Biosynthetic capacity for type-specific antigen synthesis determines the virulence of serotype III strains of group B streptococci.
- Molecular Characterization of Type-Specific Capsular Polysaccharide Biosynthesis Genes of Streptococcus agalactiae Type Ia