Exercício físico em idosos: efeito nos biomarcadores periféricos de neuroproteção / Physical activity in elderly: effect on peripheral biomarker of neuroprotection GSK3

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

23/05/2012

RESUMO

The physical activity (PA) was demonstrated to have a protective effect against Alzheimers disease, but the influence of exercising on the biomarker of neuroprotection such as Glycogen synthase kinase 3 (GSK-3) are hitherto imprecise. This study aims at assessing the effect of PA on the serum levels of GSK3. We have performed a cross-sectional observational study with 72 healthy elders, without dementia, selected and classified into two groups according to the level of PA. The GSK3 activity resulted similar in both groups; there was a tendency of inactivation of GSK3 (neuroprotective factor) among active elders and a higher activation among sedentary and highly active elders, although without statistical significance. Its possible that low-intensity physical activity may already have a protective effect. Further studies with higher number of participants and methods more accurate to measure PA will be needed to demonstrate effect of PA on the GSK3

ASSUNTO(S)

aged alzheimer alzheimer atividade física exercício exercise gsk3 gsk3 idosos physical activity

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