Excretion of Trichloroethylene Metabolites in Human Urine

AUTOR(ES)

Souček, B.

RESUMO

Five healthy subjects were exposed to known concentrations of trichloroethylene (T.R.I.) for five hours. The amount retained was calculated. The excretion of the metabolites monochloroacetic acid (M.C.A.), trichloroacetic acid (T.C.A.), and trichloroethanol (T.C.E.) in the urine was measured over the next seven to 14 days. Metabolites excreted represented an average of 73% of the dose of T.R.I. retained (M.C.A. 4%, T.C.A. 19%, T.C.E. 50%). The amount and speed of excretion of metabolites in one experiment was increased by giving glucose and insulin. The diurnal variation in the excretion of T.C.A. is emphasized.

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