Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A
AUTOR(ES)
Ma, Nan
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
It is well established that cAMP signaling within neurons plays a major role in the formation of long-term memories—signaling thought to proceed through protein kinase A (PKA). However, here we show that exchange protein activated by cAMP (Epac) is able to enhance the formation of long-term memory in the hippocampus and appears to do so independent of PKA, thus demonstrating the importance of Epac-mediated signaling in memory consolidation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2704102Documentos Relacionados
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