Eventos reprodutivos pregressos como indicador de risco para o desenvolvimento de diabetes mellitus tipo 2 em mulheres idosas
AUTOR(ES)
Demetrio Antonio Goncalves da Silva Gomes
DATA DE PUBLICAÇÃO
2006
RESUMO
The development of chronic degenerative diseases in the aging process is common event, including Diabetes Mellitus type-2 (DM-II) that play an important role among them. DM-II is caused by a polygenic base interacting with ambient factors, such as obesity and physical inactivity. The major risk factors for its development are age, ethnic group, familial history of DM-II, and central obesity. In individuals, many times genetically predisposed to, insulin resistance (RI) is the major factor responsible for the development of DM-II. RI prevalence is 10% to 25% within general population, depending on the obesity degree. Although the exact mechanisms that cause IR are unknown, this problem plays a central role in the development of several diseases. Among them, it should be pointed out DM-II, Polycystic Ovarian Syndrome, Metabolic Syndrome, and Gestational Diabetes. This study aimed to identify the importance of past reproductive events as markers to the development of DM-II among elderly women. Then, 200 elderly women were studied, being 75 diabetics and 125, non-diabetics. It was observed that past history of fetal macrosomia and spontaneous miscarriage were predictive to the development of DM-II among elderly women (p=0,001). On the other hand, frequent miscarriage, nulliparity and parity do not reveal as a risk factor for it, although this does not weaken the importance of past reproductive events to predict this risk (p=0,30; p=0,13; p=0,25),respectively.
ASSUNTO(S)
macrossomia elderly women resistÃncia insulÃnica diabetes mellitus type-2 macrosomia envelhecimento; insulina diabetes mellitus; gerontologia; aborto espontÃneo mulheres idosas abortamento diabetes mellitus tipo 2 saude coletiva miscarriage insulin resistance
ACESSO AO ARTIGO
http://www.bdtd.ucb.br/tede/tde_busca/arquivo.php?codArquivo=671Documentos Relacionados
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