Evaluation of the Polycyclic Aromatic Hydrocarbons (PAHs) bioavailability in Santos Bay through the biliary metabolites / Avaliação da biodisponibilidade de hidrocarbonetos policíclicos aromáticos (PAHs) na Baía de Santos através de metabólitos biliares

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Marine environments near urban areas, such as Santos Bay, are subjected to toxic contaminants input, as polycyclic aromatic hydrocarbons (PAHs). The PAHs bioavailability can be evaluated through biomarkers, such as biliary metabolites and 7-ethoxyresorufin-O-deethylase activity (EROD). The goal of the present study was to evaluate the PAH bioavailability in Santos Bay through the biliary metabolites, and the EROD activity as an auxiliary analysis. The samples were collected in three different regions of Santos Bay. The chosen species were: Stellifer rastrifer, Micropogonia furnieri, Nebris microps e Sphoeroides testudineus. The metabolites were analyzed through a high performance liquid chromatograph with fluorescence detector (HPLC/F). The metabolites and the EROD activity concentration varied, respectively, from 65,5 to 589 g.g-1 of bile and 6,88 a 262 pmol.min-1.mg-1 of protein. The phenanthrene and benzo(a)pirene metabolites levels were lower to N. microps and higher to S. testudineus. The naphthalene metabolites did not present significant differences among the species. There were no significant differences in the metabolites for the sampling areas and the period of collection. The PAHs bioavailability was evidenced by the metabolites and confirmed through the EROD activity.

ASSUNTO(S)

hplc/f biliary metabolites biomarcadores de exposição biodisponibilidade metabólitos biliares bioavailability polycyclic aromatic hydrocarbons biomarkers hidrocarbonetos policíclicos aromáticos baía de santos santos bay hplc/f

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