Evaluation of the acute oxidative stress after surgical trauma in the bone tissue of wistar rats. / Avaliação do estresse oxidativo agudo após trauma cirúrgico realizado em tecido ósseo de ratos wistar.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

The purpose of this work was to evaluate the oxidative stress after surgical trauma, through the activation of the NF-kB (in vivo), in wistar rats, using immunohistochemistry method on non-demineralized tissue. The results indicate a similarity among the irrigated and adrenalectomized groups of implants. The group using dexamethasone and the organic compound though presented a significant statistical result showing an expressive increase and a reduction in the second group.Conclusions: 1- The immunochemistry method may be applied on non-decalcified bone tissue which are included on Technovit® 7200VLC. 2- The titanium implants studied in this period did not maintain its position in the bone tissue showing therefore that they integrate to the bone. 3- The organic compound was effective to reduce the immunoreactivity of NF-kB with a significative reduction of the activity of this endonuclease in the bone cortical region on the studied animals. 4- More studies are required for the use of dexamethasone as an anti-inflammatory medicament on pre-surgical treatments.

ASSUNTO(S)

ossos estresse oxidativo nf-kb repair organic compound. inflammation oxidative stress reparação bone inflamação composto orgânico. nf-kb

ACESSO AO ARTIGO

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