Evaluation of Susceptibility of Human Herpesvirus 8 to Antiviral Drugs by Quantitative Real-Time PCR

AUTOR(ES)

Sergerie, Yan

FONTE

American Society for Microbiology

RESUMO

A new in vitro system based on real-time PCR was developed for evaluation of human herpesvirus 8 susceptibility to antiviral agents. Cidofovir had the greatest inhibitory activity against HHV-8 (50% inhibitory concentration [IC50], 0.43 μM) followed by ganciclovir (2.61 μM), adefovir (18.00 μM), acyclovir (31.00 μM), and foscarnet (34.15 μM). The potential therapeutic efficacy for HHV-8 (i.e., peak serum drug level/IC50) is highest for cidofovir (167) and foscarnet (22).

Documentos Relacionados

• Real-Time Quantitative PCR for Human Herpesvirus 6 DNA
• Quantitative Analysis of Human Herpesvirus 8 Viral Load Using a Real-Time PCR Assay
• Real-Time PCR as a Versatile Tool for Investigating the Susceptibility of Human Herpesvirus 6 to Antiviral Agents
• Detection of Human Cytomegalovirus DNA by Real-Time Quantitative PCR
• Quantitative Real-Time PCR Detection of Rift Valley Fever Virus and Its Application to Evaluation of Antiviral Compounds