Evaluation of lipoarabinomannan for the serological diagnosis of tuberculosis.
AUTOR(ES)
Sada, E
RESUMO
The availability of highly purified lipoarabinomannan from Mycobacterium tuberculosis in its native acylated, highly antigenic state allowed its application to the serodiagnosis of tuberculosis in patients from the Republic of Mexico. Antilipoarabinomannan immunoglobulin G antibodies in sera from 66 patients with pulmonary, miliary, and pleural tuberculosis and tuberculosis lymphadenities were measured by using the enzyme-linked immunosorbent assay against sera from a control population of healthy individuals, people with histoplasmosis, and people with lung diseases not caused by mycobacteria. The results pointed to an unexpectedly high degree of specificity of 91% and a sensitivity of 72%, comparable to figures from previous studies with other purified antigens; most of the false-positive results were for patients with histoplasmosis. Thus, lipoarabinomannan of M. tuberculosis is a potentially useful antigen for the serodiagnosis of tuberculosis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=268238Documentos Relacionados
- Detection of lipoarabinomannan as a diagnostic test for tuberculosis.
- Detection of lipoarabinomannan antibodies in patients with newly acquired tuberculosis and patients with relapse tuberculosis.
- New approaches to the rapid diagnosis of tuberculosis.
- Use of polymerase chain reaction for rapid diagnosis of tuberculosis.
- Evaluation of Roche Amplicor PCR assay for Mycobacterium tuberculosis.