Evaluation of infectivity, potential of transmission, reservoirs state and humoral immune response of pigeon (Columba livia) experimentally infected with low and high pathogenicity strains of Newcastle Disease virus (N.D.V.) of high and low pathogenicity. / Avaliação da infectividade, transmissibilidade, estado de portador (reservatório) e da resposta imune humoral de pombos (Columba livia) submetidos à infecção experimental frente a estirpes do vírus da doença de Newcastle (V.D.N.) de alta e baixa patogenicidade.
AUTOR(ES)
Adriano de Oliveira Torres Carrasco
DATA DE PUBLICAÇÃO
2009
RESUMO
Newcastle Disease (ND), is a highly contagious disease of viral etiology and several bird species are susceptible this disease. The domestic pigeon (Columba livia), has been regarded as a host and disseminating agent of ND. Therefore, a study was carried out in order to evaluate the responses of pigeons naturally or experimentally infected with this pathogen and the possible role of these birds as potential reservoirs of NDV. The disease pathogenesis and the kinetics of the host humoral immune response were studied in pigeons subjected to vaccination with live NDV strains (LaSota) and to experimental infection with a NDV strain (São João do Meriti) that affects domestic chickens (Gallus gallus). The serological response was measured by HI and the elimination of the viral genome was evaluated by RT-PCR. Vaccine strains induced high antibody levels, both in vaccinated and in sentinel birds. Clinical signs of the disease were not induced by the pathogenic strain in experimentally infected pigeons, although there was antibody production, as well as elimination of the viral genome. The high infectivity of the agent was also confirmed, since the sentinels birds presented high antibody levels, which were similar to the levels produced by infected birds.
ASSUNTO(S)
doença de newcastle newcastle disease columbiformes veterinary virology reação em cadeia por polimerase columbiformes polimerase chain reaction virologia veterinária
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