Evaluation of duration of anaesthesic action influenced by plain hyaluronidase in pterigomandibular block / "Avaliação da duração anestésica sob influência da hialuronidase injetada isoladamente no bloqueio pterigomandibular"
AUTOR(ES)
Anna Carolina Ratto Tempestini Horliana
DATA DE PUBLICAÇÃO
2006
RESUMO
The association of local anaesthetic (LA) with hyaluronidase is widely used in ophthalmic anaesthesia improving its efficacy. It was demonstrated that a fraction of molecules of the LA applied reached the nerve and the others spreads out to the tissues around. Our purpose was to verify if hyaluronidase (75 TRU) is able to prolong the duration of anaesthesic action when it was injected immediately before the end of pulpal anesthesia. It was realized 40 bilateral and symmetrical third inferior molar surgeries by the same operator, with 2% mepivacaine with epinephrine to block inferior alveolar nerve , in 20 healthy patients. In each surgeries was injected at 40 minutes hyaluronidase or placebo, in a double blinded manner. It was used electrical stimulus to evaluate pulpal anesthesia, and was done mechanical stimulus (pick) to evaluated gingival anaesthesia. The tests were done in the inferior premolar, collateral side to the surgery. In both tissues, the duration of action with hyaluronidase was longer (p<0.01) than placebo. Indirectly, these outcomes indicate that hyaluronidase redirects the molecules of LA to the nervous fiber. Regarding these experimental conditions, it is possible to conclude that hyaluronidase induce long-term local anesthesia.
ASSUNTO(S)
anestésicos locais hialuronogluconaminidase odontologia dentistry hyaluronoglicosaminidase local anesthetics
Documentos Relacionados
- Hialuronidase associada à lidocaína com epinefrina em bloqueio pterigomandibular: avaliação da latência, duração e índice de sucesso anestésico, edema facial e abertura bucal
- Efeitos cardiovasculares da lidocaína com epinefrina injetada concomitantemente à hialuronidase 75 utr/ml em bloqueio do nervo alveolar inferior
- Bloqueio peribulbar com ropivacaína: influência da hialuronidase sobre a qualidade do bloqueio e a pressão intra-ocular
- Efeito do volume da solução anestésica local aplicada no bloqueio retrobulbar na cirurgia de catarata na duração da anestesia e no conforto do paciente
- EVALUATION OF GENERATING CAPACITY RELIABILITY USING THE FREQUENCY AND DURATION METHOD