Evaluation of antimicrobial activity and toxic potential of extracts and triterpenes isolated from Maytenus imbricata
AUTOR(ES)
Rodrigues, Vanessa G., Duarte, Lucienir P., Silva, Grácia D. F., Silva, Fernando C., Góes, Jefferson V., Takahashi, Jacqueline A., Pimenta, Lúcia P. S., Vieira Filho, Sidney A.
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2012
RESUMO
The phytochemical study of hexane/ethyl ether (1:1) extract of the roots of M. imbricata, Celastraceae, resulted in the isolation and characterization of six known triterpenes: 11α-hydroxylup-20(29)-en-3-one, previously isolated from this species besides, 3β,11α-di-hydroxylup-20(29)-ene, 3,7-dioxofriedelane, 3-oxo-29-hydroxyfriedelane, tingenone and 6-oxo-tingenol. The chemical structures of these triterpenes were established by spectrometric data (IR, ¹H and 13C NMR) and through comparison with literature data. The hexane/ethyl ether (1:1), ethyl acetate and methanol extracts, and 11α-hydroxylup-20(29)-en-3-one, tingenone and 6-oxo-tingenol, showed antimicrobial properties on in vitro assays. All extracts and triterpenes, except 3β,11α-di-hydroxylup-20(29)-ene, presented toxicity demonstrated by the larvicidal effect test using Artemia salina.
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