Evaluation of anti-Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae)
AUTOR(ES)
Pavan, Fernando Rogério, Leite, Clarice Queico Fujimura, Coelho, Roberta Gomes, Coutinho, Isabel Duarte, Honda, Neli Kika, Cardoso, Claudia Andréa Lima, Vilegas, Wagner, Leite, Sergio Roberto de Andrade, Sato, Daisy Nakamura
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2009
RESUMO
The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them.
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