Evaluation of adjuvants in new triple bacterial vaccine formulation. / Avaliação de adjuvantes em novas formulações de vacina tríplice bacteriana.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

The whole cell pertussis vaccines present some reactogenicity and the acellular, less reactogenic, have prohibitive use due to its high cost. Instituto Butantan developed a less reactogenic whole cell pertussis vaccine (Plow), with low lipopolysaccharide content and an acellular vaccine (Pa), by simple and economic methodology. These preparations, combined to diphtheria and tetanus toxoids (DTPlow and DTPa, respectively), were compared with the traditional DTP, with different adjuvants: vitamin A, pulmonary surfactant, BCG, monophosphoryl lipid A (MPL) and Al(OH)3. The humoral immune response induced in mice by the different vaccine formulations, was similar and independent of the adjuvant used. The vaccines induced balanced levels of IgG1/IgG2a anti-pertussis and DTPlow showed to be less rectogenic, inducing lower levels of serum IL-6. The use of MPL suggested to induce higher protection against nasotracheal colonization in DTPa group and induced IFN-g in the DTP and DTPa groups, suggesting a possible immunemodulatory activity for Th1.

ASSUNTO(S)

vacinas vaccines vitamina a coqueluche immunological adjuvants lipopolissacarídeo vitamin a aluminium whooping cough adjuvantes imunológicos alumínio lipopolysaccharide

ACESSO AO ARTIGO

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