Evaluation of acetylcholinesterase inhibitory activity of Brazilian red macroalgae organic extracts
AUTOR(ES)
Machado, Levi P., Carvalho, Luciana R., Young, Maria Cláudia M., Cardoso-Lopes, Elaine M., Centeno, Danilo C., Zambotti-Villela, Leonardo, Colepicolo, Pio, Yokoya, Nair S.
FONTE
Rev. bras. farmacogn.
DATA DE PUBLICAÇÃO
2015-12
RESUMO
Abstract Alzheimer's disease affects nearly 36.5 million people worldwide, and acetylcholinesterase inhibition is currently considered the main therapeutic strategy against it. Seaweed biodiversity in Brazil represents one of the most important sources of biologically active compounds for applications in phytotherapy. Accordingly, this study aimed to carry out a quantitative and qualitative assessment of Hypnea musciformis (Wulfen) J.V. Lamouroux, Ochtodes secundiramea (Montagne) M.A. Howe, and Pterocladiella capillacea (S.G. Gmelin) Santelices & Hommersand (Rhodophyta) in order to determine the AChE effects from their extracts. As a matter of fact, the O. secundiramea extract showed 48% acetylcholinesterase inhibition at 400 μg/ml. The chemical composition of the bioactive fraction was determined by gas chromatography–mass spectrometry (GC–MS); this fraction is solely composed of halogenated monoterpenes, therefore allowing assignment of acetylcholinesterase inhibition activity to them.
Documentos Relacionados
- Trypanocidal activity of organic extracts from the Brazilian and Spanish marine sponges
- Extracts from Amazonian plants have inhibitory activity against tyrosinase: an in vitro evaluation
- Antimicrobial activity and acetylcholinesterase inhibition by extracts from chromatin modulated fungi
- Antibacterial activity of Brazilian Amazon plant extracts
- EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY OF PROPOLIS EXTRACTS