Evaluating enzyme replacement therapies for Anderson-Fabry disease: commentary on a recent report

AUTOR(ES)

Giugliani, Roberto, Westwood, Stephanie, Wellhoefer, Hartmann, Schenk, Jörn, Gurevich, Andrey, Kampmann, Christoph

FONTE

Genet. Mol. Biol.

DATA DE PUBLICAÇÃO

11/10/2018

RESUMO

Abstract Anderson-Fabry disease (AFD) is a rare lysosomal storage disorder. Randomized controlled clinical trials (RCTs) are preferred as the highest category of evidence, but limited availability of robust evidence in rare diseases may necessitate the use of less rigorous evidence. An analysis of cohort studies of enzyme replacement therapies for AFD published in 2017 by El Dib and coworkers made treatment recommendations that contradict previously published findings from RCTs and a systematic Cochrane review. Our commentary outlines concerns regarding selection criteria and statistical methods with their analysis.

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