Estudos espectroscopicos e quimiometricos sobre piroxicam

AUTOR(ES)
DATA DE PUBLICAÇÃO

1998

RESUMO

Piroxicam is a nonsteroidal anti-inflammatory drugs and quite efficient in the treatment of rheumatoid arthritis and other inflammatory disorders in humans. The drug is highly potent, has a long half-life of over 30 hours, but shortly after piroxicam became widely available for clinical use, it became apparent that the agent was a photosensitizer in less than 1% of patients. However, attempts to demonstrate phototoxicity in humans, laboratory animals, and cells cultures have not been successful and this is a field for investigation. Some information available in the literature about spectroscopy data of the drug and others acquired in this work were used to build models to help understanding or to find some clues about its side effects. Piroxicam was shown to have 12 possible tautomers, the tautomeric shifts resulting from fast internal proton transfer being unusually sensitive to changes in chemical substitution, solvent, and temperature. Some experimental designs were elaborated to research this system and to acquire a large amount of data with the least effort. A large quantity of data on a system increases the chance of finding relevant data, if the experimental design. However, a lot data require mathematics tools to the correctly ascertained. In this away, Chemomectrics has shown much progress since many papers on it can be found in the literature and complex systems have a chance to be studied. An experiment was planned to assess information, and PARAFAC was utilized to treat total luminescence data acquired from piroxicam cyclodextrins in aqueous medium. Knowledge derived from study of conformational analysis of piroxicam, via MOPAC/AM1, along with results obtained from PARAFAC treatment and literature data were used to make some proposals about piroxicam species and its spectroscopic behavior.

ASSUNTO(S)

fluorescencia analise conformacional espectroscopia de absorção atomica

ACESSO AO ARTIGO

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