Estudo sobre a influencia do pH gastrico na absorção de metronidazol : implicações clinicas para a erradicação do Helicobacter Pylori

AUTOR(ES)

Flavia Lucia David

DATA DE PUBLICAÇÃO

1998

RESUMO

The addition of omeprazole to the classical triple therapy for eradication of He/icobacter pylori is suggested to enhance compliance through reducing ulcer symptoms and side effects, as well as overwhelming metronidazole resistance. The aim of this study was to investigate the effects af a tive day administration period of omeprazole on metronidazole pharmacokinetics. Fourteen healthy male volunteers were selected. Plasma concentrations of metronidazole and its hydroxy-metabolite were measured by reversed phase HPLC with ultraviolet detection. Our results indicate that short-term treatment with omeprazole in healthy volunteers does not alter the extent or the rate of metronidazole absorption, and does not affect metronidazole clearance

ASSUNTO(S)

absorção farmacocinetica

Documentos Relacionados

• Estudo da influencia da acidez gastrica na farmacocinetica da furazolidona : implicações terapeuticas para a erradicação do Helicobacter pylori
• Prolonged Survival and Cytoplasmic pH Homeostasis of Helicobacter pylori at pH 1
• Helicobacter pylori survival in gastric mucosa by generation of a pH gradient.
• Avaliação da eficacia de dois esquemas terapeuticos para erradicação do Helicobacter pylori : uma visão sobre resistencia
• A influência do pH na reologia de polpas de caulim