Estudo imunohistoquímico da composição estrômato-vascular dos pólipos tonsilares / Immunohistochemical study of the stromal and vascular components of the tonsillar polyps

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

16/07/2010

RESUMO

Tonsillar polyps are nonneoplastic lesions usually composed of a variable amounts of lymphoid, vascular and connective tissues. All are generally assumed to be hamartomatous proliferations but the profile of vascular and connective components has yet to be explored. The vascular system of the tonsils is complex and includes highly specialized structures (i.e. high endothelial venules -HEVs) involved in lymphocyte homing into lymphoid tissues. In 14 tonsillar polyps and 26 control tonsils an immunohistochemical study was performed using CD34 (for blood vessels and HEVs), CD105 (for HEVs), D2-40 (for lymphatic vessels), Ki-67 (for proliferating index), collagens I and III, fibronectin and tenascin-C (for proteins of the extracellular matrix). The polyps showed increased total lymphatic area, whereas number of vessels (sanguineous and lymphatic) and blood vascular area did not differ significantly from those of control tonsils. Rare Ki-67+ endothelial cells were found. In the polyps, HEV was encountered amid lymphoid tissue and its amount correlated positively with the HEV density. The polyps also presented lesser amounts of fibronectin and collagens I and III which were distributed in a disorganized fashion. Tenascin-C expression was uncommon in the polyps and control tonsils. In conclusion, the tonsillar polyps are composed of disorganized connective tissue and lymphatic channels which can be considered hamartomatous proliferations. However, the lymphoid component is possibly reactive due to its relationship with the HEVs. The highly differentiated phenotype of the HEVs and its complex biology are not in agreement with what would be expected for a component of hamartomatous nature

ASSUNTO(S)

tecido linfoide polipos imunoistoquímica tonsila matriz extracelular lymphoid tissue polyps immunohistochemical tonsil extracellular matrix

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