Estudo histologico dos efeitos de tres drogas antibioticas sobre a evolução de tecido de granulação induzido em ratos por meio da implantação de esponja

AUTOR(ES)
DATA DE PUBLICAÇÃO

1984

RESUMO

This paper reports a study on the effects of three antibiotics with different mechanisms of action : Griseofulvin, which interferes with the nucleic-acids synthesis; Tetracyclic which interferes with the proteic synthesis and Benzathine penicillin G , which interferes with the bacterial cell wall synthesis in the granulation tissue development induced in rodents by sponge implantation. The results obtained have demonstrated that Griseofulvin at a dosage of 35,7 slightly inhibited the fibroblastic proliferation and the collagen synthesis. On the other hand, Tetracyclin at a dosage of 35,7 mg /kg and Benzathine penicilin G at a dosage of 171.425 u /K did not interfere with the granulation tissue proliferation. These results suggest that the antibiotic Griseofulvin at the dose used appears to be the therapeutic resource whenever the necessity of a slight inhibition either of fibroblastic proliferation or of the collagen synthesis. Having not apparently acted upon the granulation tissue the drugs Tetracyclin and Benzathine penicillin G would not therefore be indicated for synthesis acceleration or inhibition therapy and maturation of the same tissue

ASSUNTO(S)

tecidos (anatomia e fisiologia) esponja antibioticos - administração

ACESSO AO ARTIGO

Documentos Relacionados