Estudo dos mecanismos envolvidos na ativação policlonal dos linfócitos B durante a fase aguda da infecção pelo Plasmodium chabaudi AS. / Polyclonal antibody induction mechanisms during the acute phase of Plasmodium chabaudi AS malaria.

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

12/05/2011

RESUMO

Polyclonal B cell activation is a feature of the early spleen B cell response to human and murine malaria, which results in intense production of parasite low-affinity IgM and IgG and autoantibodies. Although this response may contribute for the initial parasite control, it may also hinder the generation of high-affinity IgG that guarantees parasite elimination and protection against secondary infections. To characterize the mechanism involved in the polyclonal B cell response to P. chabaudi AS, we have analyzed in vivo and in vitro the role of several molecules known to be involved in antibody production. According to our in vivo results, this response depends on the cooperation of CD4+ T cells with B cells. The in vitro assays shows that the expression of MHC class II molecules is crucial for B cell activation in terms of CD69 expression, proliferation and antibody production, apparently due to their requirement for T cell activation. Signaling pathways mediated by the co-stimulatory receptor CD28, CD40L and ICOS has a central role for B cell proliferative response and antibody production. This study may help to clarify the molecular basis of polyclonal B cell activation induced during acute malaria.

ASSUNTO(S)

plasmodium malaria malária protozoan infections plasmodium b lymphocytes infecções por protozoários linfócitos b

ACESSO AO ARTIGO

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