Estudo dos efeitos do fármaco propranolol para ceriodaphnia silvestrii (cladocera, crustacea) com ênfase em efeitos nas populações / STUDY OF THE EFFECTS OF THE PHARMACEUTICAL COMPOUND PROPRANOLOL TO CERIODAPHNIA SILVESTRII (CLADOCERA, CRUSTACEA) WITH EMPHASIS ON THE EFFECTS ON POPULATIONS.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

The pharmaceutical products occurrence in the aquatic environment could cause adverse effects on the human health and aquatic communities. Propranolol, non selective -blocker, is widely prescribed for the treatment of heart related diseases as angina and hypertension. Simple effect measures, like LC50, dont provide information about contaminant impacts in populations. The intrinsic population growth rate (r) is an important tool for doing research on determining the effects in population level. This work has been developed with the goal to establish the Propranolol acute and chronic toxicity to the autochthon specie Ceriodaphnia silvestrii (CLADOCERA, CRUSTACEA) with emphasis on the effects on the populations. The determined values to EC(I)50;48H were 2.87 and 2.63 mg.L-1 to distillated and natural reconstituted waters, respectively. To the chronic toxicity, the obtained values to NOEC and OEC ranged from 0.62 to 1.25 and 1.25 to 2.50 mg.L-1. As acceptance criteria to the chronic populational assays 73 neonates (±10 SD) and an intrinsic rate of natural increase of 0.596 (±0,13 SD) were established to its control for seven days of experiment with reconstituted natural water. In the sensitivity test, the obtained values to populations NOEC and OEC were 0.275 and 0.723 g.L-1 of NaCl, respectively, similar to the values in the individual chronic assays. To propranolol, the analyses indicated that the populational assays were similar or more sensitive than the individual exposition. The results in the chronic populational assays and with individuals were between 1.25 (NOEC) and 2.50 mg.L-1 (LOEC), respectively. The populational endpoints seem to be more sensitive measure. Comparing the ICP values to both populations and individuals, it is observed that the populations were more sensitive of the order of 70%.

ASSUNTO(S)

populações ecotoxicologia populações fármacos ecotoxicologia fármacos

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