Estudo do perfil salivar e sérico em gestantes e não-gestantes

AUTOR(ES)

Aline Lauria Pires

DATA DE PUBLICAÇÃO

2008

RESUMO

Aim: assess saliva and serum profile along pregnancy trimesters and follicular and luteal phases in non-pregnant. Methodology: the studied group included 50 women: 30 pregnant and 20 non-pregnant who visited the University Hospital of Brasília for treatment. The participants filled a questionnaire and underwent a dental examination in order to obtain data concerning general and oral health status. Serum and saliva collection occurred always in the morning, following standardized criteria. Resting saliva was used to assess saliva flow rate, total protein concentration and α-amylase activity. Serum/saliva paired samples were used to investigate and correlate immunoglobulin A (IgA) level, estradiol, progesterone and cortisol. Serum and salivary cortisol was also correlated to alpha-amylase activity. Kruskal-Wallis and Spearman correlation statistical tests were used to analyze the data. Results: saliva flow rate and total protein concentration, along the 3 pregnancy trimesters and during the follicular and luteal phases, did not show statistical differences. Salivary alpha-amylase activity values were superior in pregnant (p= 0,02) expressing higher values in the second trimester. Progesterone and cortisol concentrations in the serum and saliva showed correlation, increasing along the pregnancy trimesters progesterone p<0,001; cortisol p= 0,02). In non-pregnant, the levels of progesterone increased and the cortisol level showed a tendency to decrease from the follicular phase to the luteal one. The methodology used in the present study did not allow the investigation of correlation between serum/saliva estradiol. No correlation between serum and saliva IgA concentration was observed. No correlation was observed when the serum cortisol and salivary α-amylase were compared; however, an inverse correlation was detected in the levels of salivary cortisol and alpha-amylase between pregnant (p= 0,02) and non-pregnant groups (p= 0,03). Conclusion: No differences were found inter and intra the studied groups regarding saliva flow rate and total protein concentration. Other features (cortisol, progesterone and alpha-amylase) indicate that alterations on whole saliva composition might occur during pregnancy.

ASSUNTO(S)

alfa-amilase cortisol iga saliva progesterona estradiol proteína total gestação fluxo salivar ciencias da saude

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