Estudo do efeito Antinociceptivo do Eugenol / Study of the antinociceptive effect of Eugenol

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

08/01/2008

RESUMO

Eugenol is a fenolic derivative being chemically designated as 4-alil-2-metóxifenol, well-known usually as carnation essence, because this present in great quantity in the essential oil of carnation of India (Eugenia aromatic), but this present also in the cinnamon, sassafras and myrrh. Eugenol bears several pharmacological effects among them can highlight: antimicrobial, antiphlogistic, spasmolytic, antiseptic, antipyretic, antioxidant, antinociceptive. The goal of this study was to investigate the local anesthetic effect of eugenol managed by way intraplantar in mice and to compare with capsaicin effect and of lidocaine. For this investigate eugenol effect, of capsaicin and of lidocaína in formalin test. Eugenol in the doses of 0,01; 0,1; 0,3; 1; 3 e 10 mg/place, managed by way intraplantar, did not promote nociception increase regarding the control in the test first phase. In formalin test eugenol the same concentrations decreased the sensibility in 70,69%, 43,71%, 53,76%, 54,98% and 64,57% respectively in the doses of 0,1; 0,3; 1; 3 and 10mg/place, suggesting eugenol effect in the pain of neurogenic origin, that corroborates with results presented in the literature where eugenol, in low concentrations, is an inhibiter of the nervous activity of reversible form. The pretreatment with capsazepina and the strings destruction C afferent confirm eugenol action in the receptor TRPV1, because eugenol does not decrease for nociception provoked by formalin in none of the two tests. For capsaicin, regarding the control, effect is effective in decrease for nociception generated by formalin in the doses of 0,01; 0,1; 0,3; 1; 3 e 10mg/place in the test first phase. This effect, probably, is due to the inhibition of the channels of dependent calcium voltage, so much by the capsaicin as by eugenol. For lidocaína was used as positive control of the test in the doses 0,01; 0,1; 0,3; 1; 3; 10mg/place. Your effect is effective, in nociception decrease provoked by formalin in the neurogenic phase of the test, in all tried doses. However the anesthetic effect of eugenol in the dosi of 0,1mg/place was greater than the presented by lidocaína at the same quantity. That effect, probably, should eugenol action and of lidocaine in the sodium channels activated by voltage that are important for the beginning and action potential propagation of excitable cells, including the 17 sensory neurons. With that can conclude that the eugenol in small doses does not increase for nociception; probably owns effect antinociceptive local by the inhibitory action of the receptors TRPV1; The eugenol, for capsaicin and for lidocaine own effect antinociception local in formalin test first phase

ASSUNTO(S)

anestésico eugenol lidocaína teste formalina fisiologia anesthetic eugenol lidocaína formalin test

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