Estudo da microcirculação na hanseníase virchowiana com o uso da microscopia de luz ortogonal polarizada e com laser-doppler fluxometria / Microcirculation s research in leprosy with orthogonal polarization special imaging and laser doppler

AUTOR(ES)

Curt Mafra Treu

DATA DE PUBLICAÇÃO

2010

RESUMO

Leprosy is an infectious disease with unique characteristics. One of them is the fact that it compromises not only the cutaneous and adnexial innervation, but also the innervation of the cutaneous microcirculation. Several articles indicate the impact of disautonomy on the microcirculatory level, citing the example of changes in vasomotor level. The present study proposes to evaluate morphology and microvascular reactivity of the cutaneous microcirculation of the virchowian leprosy. Methods employed in the study were: the Cytoscan, which uses the orthogonal polarized light, the Fourier analysis of the laser Doppler signal to study vasomotion, and the laser Doppler flowmetry associated with iontophoresis of vasoactive substances (acetylcholine, sodium nitroprusside and norepinephrin). Ten patients with virchowian leprosy, without any other comorbidity that could modify the microvascular parameters were evaluated and their results were compared to ten controls without leprosy or any other comorbidity. Regarding the vasomotion, no statistical significant differences were noticed between the groups. Our data are in agreement with the vasomotions miogenic origin theory. According to iontophoresis of vasoactive substances, it was found that there is a reduced endothelial-dependent and endothelial-independent vasodilation in patients with leprosy while tests by direct visualization we observed an increase in the size of capillaries, as well as changes in their morphology. The results suggest that the significant changes in morphology and vascular reactivity of skin microcirculation are probably due to the long period of innervatory changes arising from leprosy.

ASSUNTO(S)

medicina luz ortogonal polarizada microcirculação microcirculation sistema nervoso hanseníase iontophoresis orthogonal polarization spectral imaging leprosy lser doppler laser doppler nervous system iontoforese

Documentos Relacionados

• Estudo das alterações do fluxo capilar pancreático após infusão de ceruleína avaliado por laser-Doppler em ratos
• Estudo da microcirculação na polpa dentária durante a movimentação ortodôntica via técnica Laser Doppler
• Effects of buflomedil and pentoxifylline on hamster skin-flap microcirculation: prediction of flap viability using orthogonal polarization spectral imaging
• Hanseníase borderline virchowiana
• Contribuição do estudo dos cabelos com microscopia de luz polarizada ao diagnóstico diferencial das síndromes de Chédiak-Higashi and Grisceli-Prunieras