Estudo da imunorreatividade das proteínas ligantes de cálcio na neuroquímica da medula espinal de ratos submetidos à atividade física espotânea na roda de corrida. / Study of the imunoreativite of ligantes calcium proteins in the neurochemistry of the espinal marrow of submitted rats the spontaneous physical activity in the race wheel

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Actions of the physical activity in the neurochemistry focuzing calcium-bindin proteins and the activation of the glial cells in the spinal cord of the rat were investigated with imunohistochemistry over. Male wistar adult rats were divided in two groups: trained, which animals exercised in the wheel running for 4 and 14 nigths; and sedentary, which animals were maintained in private box without wheel running. After that period rats were sacrificed and their spinal cords were processed to imunohistochemistry. Calcium-bindin proteins neuronal (parvalbumin and calbindin) and glial (S100) were evaluted. The activity promoted a decrese in the imunoreativite of the calbindin protein in the torácic level of the posterior horn (lamina I and II of Rexed), and lateral spine nucle after 14 days. In the lombar level, decrese in the posterior horn was also found. Animals submited to physic activity for 4 days showed an increased in the imunoreatived area of parvalbumin. Similar effect was observed all of groups that were treineds for 4 e 14 days. However, in the cuneiforne fascicule, parvalbumin decreased. The S100 protein showed decresed in the anterior horn. In conclusion volunteer phisical activity changed the pattern of the calcium-bindin protein immunoreactivity in the spinal cord, effect than can be associated to neuroplasticity.

ASSUNTO(S)

calbindin neurochemistry proteínas s100 physical activity atividade física neuroquímica plasticidade neuronal s100 proteins neuronal plasticity parvalbumina parvalbumins calbindina

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