Estudo da fonoforese de ciclofenaco dietilamonio em voluntarios sadios / Study of diclofenac diethylammonium phonophoresis in healthy human volunteers

AUTOR(ES)

Claudio Fusaro

DATA DE PUBLICAÇÃO

2006

RESUMO

Transdermal drug delivery with therapeutic ultrasound, method called phonophoresis, offers many advantages when compared to other drug delivery methods. The aim of this study was to verify the influence of ultrasound on the transdermal delivery of diclofenac diethylammonium (Cataflam Emulgel®, Novartis) post phonophoresis in healthy volunteers. Twelve healthy human volunteers were submitted to topical application of Cataflam Emulgel® on 150cm2 area on the dorsum. In the Control Group, the volunteers received topical application with the ultrasound switched off and the Test Group received topical application by phonophoresis. The diclofenac plasma concentration was measured by high perfomance liquid chromatography (HPLC) during a period of 8h after dosing. We provided evidence that transdermal application of diclofenac diethylammonium by phonophoresis, in a single dose, has not induced plasmatic concentration increase when compared to topical application alone

ASSUNTO(S)

ultrasound topical administration fonoforese ultra-som administração topica phonophoresis agentes antiinflamatorios

Documentos Relacionados

• Estudo de toxicologia clínica de três fitoterápicos à base de associações de plantas, mel e própolis em voluntários sadios
• Study of comparative bioavailability among two formulations containing sodic levothyroxine in healthy volunteers.
• Pharmacokinetics interaction between diclofenac and ranitidine after peroral administration of Voltaren 50 to healthy volunteers
• Avaliação da biodisponibilidade relativa de duas formulações contendo levocetirizina em voluntarios sadios
• Estudo comparativo do conforto e efeitos adversos de interfaces para ventilaÃÃo nÃo invasiva em voluntÃrios sadios