Estudo da distribuição da proteína S100b em encéfalo de ratos. / Distribution of the S100b protein specific in brain of the rats.
AUTOR(ES)
Leila Maria Guissoni Campos
DATA DE PUBLICAÇÃO
2007
RESUMO
S100b protein is expressed primarily by astroglia in the brain, and practice functional implication of S100b secretion by astrocytes into the extracellular space is scant but there is substantial evidence that secreted glial S100b exerts trophic or toxic effects depending on its concentration. We provide here a detailed description of the distribution of the calcium-binding protein S100b in and glial elements in the encefalo of rats. The distribution of S100-like immunoreactivity was analyzed by antisera: monoclonal, the b subunit (S100b) of this protein. All sera showed glial positive elements, which were more abundant in the brainstem than in the prosencephalon. S100-immunoreactive was detected in glial elements, in different regions of the telencephalon, diencephalon and mesencephalon. This distribution appears very similar to that, as well as to sparse observations on different vertebrates. Therefore, our results suggest that the distribution pattern of this protein in glial elements is highly conserved between the species.
ASSUNTO(S)
basal s100b protein neuroglia rats. ratos. proteína s100b brain distribuição (análise funcional) neuroglia distribution cérebro basal
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