Estudo comparativo entre agregação plaquetária por turbidimetria e impedância elétrica em relação a pacientes sob terapia antiplaquetária a base de ácido acetilsalicílico / Comparative study between platelet aggregation by turbidimetric and impedance methods in patients under acetylsalicilic acyd antiplatelet therapy

AUTOR(ES)
DATA DE PUBLICAÇÃO

2010

RESUMO

The adhesion of platelets in the blood vessel wall and subsequent aggregation are crucial events in both bleeding and thrombosis. The hyperaggregation (excessive aggregation) of platelets can cause the formation of a thrombus and subsequent occlusion of blood vessels leading to an ischemic process. Antiplatelet therapy with acetylsalicylic acyd reduces by 25% the risk of myocardial infarctions, non-fatal strokes or deaths from vascular causes in patients at high risk, regardless of sex or age. To laboratory evaluation of the effectiveness of this therapy, the method most used is the platelet aggregation test, which can be done in two methods, the turbidimetric and electrical impedance. With this scenario, the objective of the study is to compare these two methodologies for monitoring the treatment. For such purpose, blood samples from 30 adult patients (mean 42 years) of both sexes who make regular use of the drug was analyzed using the two methodologies, and their results was analyzed and compared. The studys results showed little difference statistically significant (p <0.05) between the two methods with the main stimulant agents, indicating that the method of electrical impedance can be used in routine laboratory instead or complementing the methodology of turbidimetric for monitor antiplatelet therapy by acetylsalicylic acyd

ASSUNTO(S)

Ácido acetilsalicilico agregação plaquetária aspirin blood platelets electric impedance impedância elétrica nephelometry and turbidimetry plaquetas platelet aggregation turbidimetria

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