Estudo comparativo da susceptibilidade de bovinos e bufalinos à intoxicação cúprica acumulativa / Comparative study of the susceptibility of cattle and buffalo to accumulative copper poisoning

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

The main aim of this project is to carry out a comparative study of the susceptibility of cattle (crossbreed) and buffalo (Murrah) to accumulative copper poisoning, by infusion of increasing doses of copper, and studying some clinical and blood variables and the liver Cu concentration. Ten cattle and 10 buffalo yearling steers were randomly distributed into two copper supplemented groups (BOV Cu; BUF Cu; n = 6) and two control groups (BOV; BUF; n = 4). The two former groups received initially 2 mg Cu/kg/BW (as CuSO4..5H2O) daily for a week; every following week, up to the end of the experiment (105th d), this initial dose was increased of 2 mg Cu/kg/BW. For three times during the experiment (day zero, 45thand 105th d) a liver biopsy was carried out to evaluate the degree of copper accumulation in this organ; the body weight and clinical examination was followed weekly, as far as blood samples were withdrawn. Three cattle and two buffaloes supplemented with copper presented clinical picture and/or laboratory findings indicative of accumulative copper poisoning (ACP), and died thereafter. There was no difference in the frequency of mortality between cattle and buffalo (P >0.87) Two different clinical picture were seen, the classical (one cattle and one buffalo) and one atypical (two cattle and one buffalo) characterized by remarkable high levels of liver copper, progressive hyporexia followed by anorexia, dehydration, severe apathy, decreased rumen movements, oliguria and death. Some of animals were resistant to ACP in spite of high accumulative levels of copper. The liver copper concentration were higher in cattle than buffalo (4.389 and 2.052 ppm, respectively). Cattle with ACP increased their zinc liver concentration at the final stages of the poisoning. The presence of high serum activity of gamma glutamyltransferase (GGT) (>24.6 U/L) and aspartate aminotransferase (AST) (>90 U/L) for cattle and GGT (>20 U/L) for buffalo indicated effectively the high accumulation of copper in liver (>1000 ppm). No poisoned animals developed renal insufficiency, but one buffalo with atypical picture.

ASSUNTO(S)

copper fígado bovinos buffalo cobre búfalos poisoning cattle liver intoxicação

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