Estudo clinico epidemiologico das hepatites infecciosas em individuos infectados pelo virus da imunodeficiencia humana

AUTOR(ES)
DATA DE PUBLICAÇÃO

1999

RESUMO

HIV infected subjects present a lot of infections and they are at risk for virus hepatitis, specially due to the similarities transmission. The aim of this study was to analyze clinical, laboratory and histologic abnormalities ofhepatitis in mv infected subjects. We have studied 232 HIV seropositive subjects, most of them with no signs of AIDS. In 116 (50%) of them, the way of transmission was by sexual intercourse and in 74 (31,9%) subjects the transmission of mv occured by blood , specially among intravenous drug users. Only 66 (28,4%) subjects presented some gastrointestinal symptom and 03 (1,3%) presented jaundice during physical examination. The liver was palpable in 57,8% of the subjects and very rarely hepatic insufficiency or portal hypertension was observed. The alkaline phosphatase , bilirubin and albumin levels were normal in more than 90% of the subjects. Hypergammaglobulinemia was found in 131 (66,2%) subjects. The AST levels were elevated in 49(21,2%) subjects. Statistically, a significant correlation was observed between the AST levels increase and the ingestion of potentially hepatotoxic drugs (p=0,05). The ALT levels were elevated in 39% ofthe subjects. In our study, VHA IgG antibodies were detected in 155 (99,4%) subjects, 12 (5,3%) subjects were HBsAg positive, 100{ 44,2%) were anti-HBcAg positive and 119 (53,8% ) subjects were anti-HCV positive. Relationship was statistically significant between mv blood transmission and the positivity for anti-HCV (p<0,05). Otherwise, there was a significant positive correlation between the positivity of anti-HBcAg and mv sexual transmission (p<0,05). We could demonstrate statistically significant relationship between the presence of anti-HCV and the elevation of ALT (p<0,05). The histologic findings in liver biopsies have shown a predominance of chronic active hepatitis in these subjects (56,7%)

ASSUNTO(S)

hiv (virus) aids (doença) hepatite não-a hepatites por virus não-b

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