Essential function for ErbB3 in breast cancer proliferation

AUTOR(ES)

Perez-Nadales, Elena

FONTE

BioMed Central

RESUMO

The overexpression of the ErbB family of tyrosine kinase receptors is thought to be important in the development of many breast tumours. To date, most attention has focused on the ErbB2 receptor. Now, in a recent report, it has been shown that ErbB3 is a critical partner for the transforming activity of ErbB2 in breast cancer cells. Importantly, the proliferative signals from this transforming complex appear to act via the PI-3 kinase pathway.

Documentos Relacionados

• The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation
• Neuregulin receptors, erbB3 and erbB4, are localized at neuromuscular synapses.
• The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system
• ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.
• Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases