Equivalence between Haseman-Elston and Variance-Components Linkage Analyses for Sib Pairs
AUTOR(ES)
Sham, P. C.
FONTE
The American Society of Human Genetics
RESUMO
The Haseman-Elston regression method offers a simpler alternative to variance-components (VC) models, for the linkage analysis of quantitative traits. However, even the “revisited” method, which uses the cross-product—rather than the squared difference—in sib trait values, is, in general, less powerful than VC models. In this report, we clarify the relative efficiencies of existing Haseman-Elston methods and show how a new Haseman-Elston method can be constructed to have power equivalent to that of VC models. This method uses as the dependent variable a linear combination of squared sums and squared differences, in which the weights are determined by the overall trait correlation between sibs in a population. We show how this method can be used for both the selection of maximally informative sib pairs for genotyping and the subsequent analysis of such selected samples.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1226141Documentos Relacionados
- Transformation of Sib-Pair Values for the Haseman-Elston Method
- Método de Haseman-Elston e suas modificações no estudo de genes controladores de característica quantitativa
- Testing for Genetic Linkage in Families by a Variance-Components Approach in the Presence of Genomic Imprinting
- Nonpaternity in Linkage Studies of Extremely Discordant Sib Pairs
- Type 2 diabetes: Evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs