Epigenetic reprogramming and induced pluripotency

AUTOR(ES)

Hochedlinger, Konrad

FONTE

Company of Biologists

RESUMO

The cloning of animals from adult cells has demonstrated that the developmental state of adult cells can be reprogrammed into that of embryonic cells by uncharacterized factors within the oocyte. More recently, transcription factors have been identified that can induce pluripotency in somatic cells without the use of oocytes, generating induced pluripotent stem (iPS) cells. iPS cells provide a unique platform to dissect the molecular mechanisms that underlie epigenetic reprogramming. Moreover, iPS cells can teach us about principles of normal development and disease, and might ultimately facilitate the treatment of patients by custom-tailored cell therapy.

Documentos Relacionados

• Pluripotency deficit in clones overcome by clone–clone aggregation: epigenetic complementation?
• Embryonic hybrid cells: a powerful tool for studying pluripotency and reprogramming of the differentiated cell chromosomes
• Epigenetic reprogramming in the mammalian embryo: struggle of the clones
• Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro
• Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes