Epigallocatechin Gallate Synergistically Enhances the Activity of Carbapenems against Methicillin-Resistant Staphylococcus aureus

AUTOR(ES)

Hu, Zhi-Qing

FONTE

American Society for Microbiology

RESUMO

Combinations of carbapenems and epigallocatechin gallate (EGCg; a main constituent of tea catechins) showed potent synergy against 24 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). MICs of imipenem in the presence of EGCg at 3.125, 6.25, 12.5, and 25 μg/ml, were restored to the susceptible breakpoint (≤4 μg/ml) for 8, 38, 46, and 75% of the MRSA isolates, respectively. Similar results were also observed for combinations of panipenem or meropenem and EGCg. Therefore, the combinations may be worthy of further evaluation in vivo against MRSA infection.

Documentos Relacionados

• Mechanism of Synergy between Epigallocatechin Gallate and β-Lactams against Methicillin-Resistant Staphylococcus aureus
• Activity of ciprofloxacin against methicillin-resistant Staphylococcus aureus.
• Bactericidal activity of antiseptics against methicillin-resistant Staphylococcus aureus.
• Comparative in vitro activity of coumermycin against methicillin-resistant Staphylococcus aureus.
• Methicillin-resistant Staphylococcus aureus.