Enzymatic Phosphorylation of Streptomycin by Extracts of Streptomycin-producing Strains of Streptomyces

AUTOR(ES)

Miller, Ann L.

RESUMO

Extracts of post-exponential phase mycelia of Streptomyces bikiniensis ATCC 11062, and other streptomycin-producers, catalyze phosphorylation of streptomycin and dihydrostreptomycin with adenosine-5′-triphosphate. The phosphate is esterified with an —OH group of the streptidine moiety. It is suggested that O-phosphoryl-streptomycin might serve as an intracellular precursor of extracellular streptomycin or as a detoxification product of streptomycin or that it might serve an unknown physiological function in the producing organism.

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