Entry of Bartonella bacilliformis into erythrocytes.
AUTOR(ES)
Benson, L A
RESUMO
Bartonella bacilliformis, which causes the human diseases Oroya fever and verruga peruana, binds to human erythrocytes in vitro and produces substantial and long-lasting deformations in erythrocyte membranes, including cone-shaped depressions, trenches, and deep invaginations. The deforming force is probably provided by the polar flagella of these highly motile bacteria. Deep invaginations containing bacteria are commonly seen, and membrane fusion at the necks of the invaginations leads to the formation of intracellular vacuoles containing bacteria. Fluorescent compounds present externally render the vacuoles fluorescent and, occasionally, lightly fluorescent cells are seen, suggesting that the vacuoles sometimes rupture to admit the bacteria to the cytoplasm. Vacuoles present in fluorescent erythrocytes prepared by preloading the erythrocytes with fluorescent compounds are seen as dark areas from which the fluorescent marker is excluded. Entry of the bacteria appears to be the result of a process of forced endocytosis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=260167Documentos Relacionados
- Characterization of Bartonella bacilliformis flagella and effect of antiflagellin antibodies on invasion of human erythrocytes.
- Characterization of a two-gene locus from Bartonella bacilliformis associated with the ability to invade human erythrocytes.
- Plasmodium chabaudi p68 serine protease activity required for merozoite entry into mouse erythrocytes.
- Physical map of the Bartonella bacilliformis genome.
- Identification of outer membrane proteins of Bartonella bacilliformis.