ENaC at the Cutting Edge: Regulation of Epithelial Sodium Channels by Proteases*
AUTOR(ES)
Kleyman, Thomas R.
FONTE
American Society for Biochemistry and Molecular Biology
RESUMO
Epithelial Na+ channels facilitate the transport of Na+ across high resistance epithelia. Proteolytic cleavage has an important role in regulating the activity of these channels by increasing their open probability. Specific proteases have been shown to activate epithelial Na+ channels by cleaving channel subunits at defined sites within their extracellular domains. This minireview addresses the mechanisms by which proteases activate this channel and the question of why proteolysis has evolved as a mechanism of channel activation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2742807Documentos Relacionados
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