Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
AUTOR(ES)
Björklund, Lars M.
FONTE
The National Academy of Sciences
RESUMO
Although implantation of fetal dopamine (DA) neurons can reduce parkinsonism in patients, current methods are rudimentary, and a reliable donor cell source is lacking. We show that transplanting low doses of undifferentiated mouse embryonic stem (ES) cells into the rat striatum results in a proliferation of ES cells into fully differentiated DA neurons. ES cell-derived DA neurons caused gradual and sustained behavioral restoration of DA-mediated motor asymmetry. Behavioral recovery paralleled in vivo positron emission tomography and functional magnetic resonance imaging data demonstrating DA-mediated hemodynamic changes in the striatum and associated brain circuitry. These results demonstrate that transplanted ES cells can develop spontaneously into DA neurons. Such DA neurons can restore cerebral function and behavior in an animal model of Parkinson's disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=122367Documentos Relacionados
- Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model
- Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry
- Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation
- Will embryonic stem cells be a useful source of dopamine neurons for transplant into patients with Parkinson's disease?
- Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease