Efg1 Involved in Drug Resistance by Regulating the Expression of ERG3 in Candida albicans
AUTOR(ES)
Lo, Hsiu-Jung
FONTE
American Society for Microbiology
RESUMO
The ERG3 gene in Candida albicans was identified as a gene whose mRNA level was higher in the cph1/cph1 efg1/efg1 double mutant than in the wild-type cells. Further study showed that Efg1, but not Cph1, negatively regulated ERG3. Mutations in EFG1 consistently increased the susceptibility of the cells to antifungal agents.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=549285Documentos Relacionados
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