Effects of the topical application of an ethyl acetate fraction from Vernonia scorpioides on excisional wounds infected with Staphylococcus aureus in rats

AUTOR(ES)

Kreuger, Maria Regina Orofino, Farias, Bruna Gonçalves, Moreira, Janaína, Blind, Luise Zozula, Amoah, Solomon Kweku Sagoe, Leite, Andreia Siqueira, Biavatti, Maique Weber, van Hoof, Tom, D'Herde, Katharina, Cruz, Alexandre Bella

FONTE

Revista Brasileira de Farmacognosia

DATA DE PUBLICAÇÃO

21/10/2011

RESUMO

We investigated the healing process on excisional wounds infected with Staphylococcus aureus in rats, treated with 50 µL of ethyl acetate III from Vernonia scorpioides (Lam.) Pers., Asteraceae, rifamycin diethylamide B 25 mg, or saline. The lesions were measured daily and after seven days were surgically removed and histologically processed. The results indicate a favorable action of the EAIII, demonstrated by the increased wound contraction, smaller area of necrotic tissue, good development of granulation tissue, extensive extracellular matrix deposition and epithelial regeneration. This sub-fraction was phytochemically investigated in parallel studies, revealing the presence of sesquiterpene lactones (glaucolides and hirsutinolides) such as diacethylpiptocarphol and related hirsutinolides, flavonoids and cinnamic acid derivatives and also a new polyacetylene, which have been previously published. Results support the effectiveness of V. scorpioides antimicrobial activity in infected wound healing in rats.

Documentos Relacionados

• Effects of the topical application of the extract of Vernonia scorpioides on excisional wounds in mice
• The effects of photobiomodulation therapy on Staphylococcus aureus infected surgical wounds in diabetic rats. A microbiological, histopathological, and biomechanical study
• Distribution of systemically administered ampicillin, benzylpenicillin, and flucloxacillin in excisional wounds in diabetic and normal rats and effects of local topical vasodilator treatment.
• Cytotoxic activity of the dichloromethane fraction from Vernonia scorpioides (Lam.) Pers. (Asteraceae) against Ehrlich's tumor cells in mice
• The effects of low level laser therapy on Staphylococcus aureus infected third-degree burns in diabetic rats