Effects of the exposure to cigarette smoke and residual oil fly ash (ROFA) in lungs of C57/Bl6 mice / Efeito da exposição à fumaça de cigarro e ao resíduo de óleo diesel (ROFA) em pulmões de camundongos C57/BI6

AUTOR(ES)

Paolo José Cesare Biselli

DATA DE PUBLICAÇÃO

2008

RESUMO

Many of the mechanisms leading to CPOD (Chronic Pulmonary Obstructive Disease) are not completely understood. In the present study, we exposed C57/Bl6 mice, for two months, to cigarette smoke and/or ROFA (Residual Oil Fly Ash). Animals exposed to cigarette smoke had an increased in proximal airways resistance, probably due to the thickening of airways walls that followed changes in epithelial cells. These animals also had a small degree of emphysema, once air spaces enlargement could be noticed in circumscribed lung areas. We observed no inflammatory cells recruitment, elastic or collagen fibers deposition or increases in oxidative stress, measured by staining Isoprotane8. This study shows an early stage of the CPOD development, in which we can detect changes in epithelial cells and a small degree of emphysema, which could be mediated by these same epithelial cells

ASSUNTO(S)

tobacco environmental pollution chronic obstructive/physiopathology doença pulmonar obstrutiva crônica/fisiopatologia mice pulmonary emphysema tabaco pulmonary disease camundongos poluição ambiental enfisema pulmonar

Documentos Relacionados

• Efeitos do resíduo da queima de óleo diesel (ROFA) e da inflamação pulmonar alérgica crônica em três linhagens de camundongos
• Aerobic exercise attenuates pulmonary alterations induced by exposure to cigarette smoke in mice
• Short-term exposure of mice to cigarette smoke and/or residual oil fly ash produces proximal airspace enlargements and airway epithelium remodeling
• A exposição a fumaça de cigarro altera distribuição de tecido adiposo branco de camundongos fêmeas jovens
• Efeitos benéficos do tratamento com óleo de peixe em camundongos c57bl/6 alimentados com dieta hiperlipídica e rica em sacarose